UCR

Department of Mathematics



Interdisciplinary Seminar on Mathematical & Computational Modeling


Interdisciplinary Seminar on Mathematical & Computational Modeling

Contact: Dr. Mark Albermalber@ucr.edu 

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Upcoming Talks

March 5th, 2019
11:10 a.m. - 3:30 p.m. Skye 268

Prof. Qixuan Wang, UC Riverside Mathematics Department

Title: "Impacts of Cellular Heterogeneity on Hair Follicle Growth Dynamics"

Abstract: Hair follicle is a mini-organ in mammalian skin that can undergo cyclic growth, whose spatial and temporal dynamics are under tight regulatory control mechanisms from both intra- and extra-follicular environment. Recent experimental results have elucidated how certain signaling pathways regulate cell divisions, differentiation and programmatic death in different parts of the follicle. However, an integrated regulatory mechanism of hair follicle growth dynamics is still unclear at present. In particular, two crucial questions stay unresolved: 1) how does the hair follicle know if it has reached the maximum length, and 2) how does the hair follicle know when to terminate anagen and enters catagen? Using a novel multi-scale model, we discover how a cooperative signaling network regulates the cell lineage dynamics during anagen and early catagen. Preliminary modeling results indicate that cellular heterogeneity in response to signals play an important role in controlling the hair follicle growth dynamics. In particular, we find that heterogeneity in the responses of outer root sheath cells to proliferation vs. differentiation signals determines the hair follicle length. Next, heterogeneity in the responses of matrix cells to proliferation vs. differentiation signals allows longer anagen by enhancing cell competitions. Moreover, the heterogeneous response of matrix cells to the signals allows great anagen duration variability subjected to Bmp level changes.


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