UCR

Department of Mathematics



Interdisciplinary Seminar on Mathematical & Computational Modeling


Interdisciplinary Seminar on Mathematical & Computational Modeling

Contact: Dr. Mark Albermalber@ucr.edu 

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Upcoming Talks

December 4th, 2018
2:10 - 3:30 Skye 268

Prof. Mona Eskandari Department of Mechanical Engineering, University of California, Riverside

Title: "Pulmonary Healthcare"

Abstract: Lung disease is the leading cause of death worldwide and yet,pulmonary mechanics and airway obstruction remain drastically understudied.Computational modeling paired with experimental characterization offers an iterative framework for establishing airway mechanics and exploring tissue remodeling due to disease-driven adaptation. Our simulations integrate the theory of finite growth, continuum mechanics, and nonlinear finite element analysis; results rationalize clinical observations and elucidate the complex phenomenon of airway obstruction. Our complementary tissue experiments address the pressing need for understanding the biophysical response of airways, characterizing mechanical and viscoelastic anisotropyand and heterogeneity. Findings inform the first structurally-reinforced constitutive model of proximal and distal bronchi, directly providing the foundation for pulmonary fluid-structure interaction research. This combinatory computational-experimental approach ultimately sets the stage for translational discoveries by enabling predictive modeling, advanced medical diagnostics, and optimized interventions in pulmonary healthcare.

Bio: Mona Eskandari is an Assistant Professor in the Department of Mechanical Engineering (Cooperating Faculty in the Department of Bioengineering, collaborating with the School of Medicine's multidisciplinary BREATHE center) at UC-Riverside.Prior to her postdoctoral fellowship at UC-Berkeley, she received her doctorate and master's degree from Stanford University, and her bachelor’s degree from the University of Arizona, where she was also a Nugent medalist. She was granted the University of California Provost's Engineering Research Fellowship, and was previously named a National Science Foundation Graduate Research Fellow, a DARE Doctoral Fellow,and a Stanford Graduate Science and Engineering Fellow. Her area of expertise is computational modeling and experimental characterization of biological systems,with an emphasis on pulmonary mechanics. Eskandari received the Early Engineering Educator Award from the American Society for Engineering Education for innovative teaching, and the prestigious K. Patricia Cross Future Leaders of Higher Education Award from the Association of American Colleges and Universities.

 

 

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Past Talks

Nov. 27th, 2018
2:10 - 3:30 Skye 268

Dr. Prof. Maksim Plikus Department of Developmental and Cell Biology Stem Cell Research Center University of California, Irvine

Title:Using math to understand how skin heals itself"

Abstract: Skin is the largest organ in our body and it functions to protect us from a variety of external insults. Being at the forefront of bodily defenses, skin often becomes injured, entering the state of emergency that launches rapid and efficient wound healing response.The latter requires coordinated activation and mobilization of multiple skin cell types, including dormant skin stem cells and resident immune cells.While most of the time, wound healing in mammals, including mice and humans,culminates with the formation of a scar tissue, some animals can heal wounds by regeneration, when both hair follicles and fat cells form anew. Systems Biology approaches are required to properly understand cellular and signaling basis of scaring vs. regeneration in skin wounds. In my talk, I will discuss the state of knowledge in this field and will share how we study wound regeneration with the help of mathematical modeling and bioinformatic analyses.

Bio: Dr. Maksim Plikus completed his PhD and first post-doctoral training at the University of Southern California, working with Dr. Cheng-Ming Chuong.Among other research, his studies identified new mechanism of hair growth coordination by long-range signals. During his second post-doctoral training with Dr. George Cotsarelis at the University of Pennsylvania, Dr. Plikus identified new phenomenon of fat cell regeneration in skin wounds. He joined the University of California Irvine in 2012, where he is currently Associate Professor. His lab continues to study mechanisms of skin homeostasis and regeneration,including with the help of mathematical modeling. Recently his lab published several




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Office Hours: 8:30 a.m. - 11:45 a.m. & 1:00 p.m. - 4:45 p.m.

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